Data estimated from VAERS and OpenVAERS; serious reports (~15% of total) include life-threatening and permanently debilitating events.
| Year | Total VAERS Reports | Est. Life-Threatening/Permanently Debilitating Reports | Est. Monthly Average Reports | Notes |
|---|---|---|---|---|
| 1995 | 3130 | 470 | 39 | Early VAERS; routine vaccines; low baseline. |
| 1996 | 3230 | 485 | 40 | Stable reporting; routine vaccines (e.g., DTP, polio). |
| 1997 | 3390 | 509 | 42 | Consistent with early years; routine vaccine monitoring. |
| 1998 | 3030 | 455 | 38 | Slight dip; stable pre-2000 baseline. |
| 1999 | 3810 | 572 | 48 | Gradual increase; routine vaccines dominate. |
| 2000 | 6060 | 909 | 76 | Rise in reports; improved awareness/reporting systems. |
| 2001 | 6970 | 1046 | 87 | Continued increase; routine vaccines. |
| 2002 | 8300 | 1245 | 104 | Steady growth in reporting. |
| 2003 | 8950 | 1343 | 112 | Consistent with early 2000s trends. |
| 2004 | 9680 | 1452 | 121 | Incremental rise; routine vaccine focus. |
| 2005 | 9280 | 1392 | 116 | Stable reporting; no major changes. |
| 2006 | 10700 | 1605 | 134 | Slight increase; possible new vaccine introductions. |
| 2007 | 19170 | 2876 | 240 | Notable rise; HPV vaccine introduced (2006). |
| 2008 | 21090 | 3164 | 264 | Continued increase; HPV and flu vaccine reporting. |
| 2009 | 20750 | 3113 | 259 | H1N1 vaccine rollout; temporary spike. |
| 2010 | 17780 | 2667 | 222 | Post-H1N1 decline; return to baseline. |
| 2011 | 15130 | 2270 | 189 | Stable; routine vaccines dominate. |
| 2012 | 16280 | 2442 | 204 | Slight increase; consistent reporting. |
| 2013 | 17600 | 2640 | 220 | Incremental rise; no major vaccine changes. |
| 2014 | 21620 | 3243 | 270 | Increase; possible improved reporting systems. |
| 2015 | 31820 | 4773 | 398 | Stable; routine vaccines (e.g., flu, MMR). |
| 2016 | 36110 | 5417 | 451 | Slight increase; no major vaccine introductions. |
| 2017 | 33520 | 5028 | 419 | Consistent with prior years; routine vaccine monitoring. |
| 2018 | 43570 | 6536 | 545 | Moderate increase; possible rise in flu vaccine reporting. |
| 2019 | 44840 | 6726 | 561 | Stable; pre-COVID baseline for routine vaccines. |
| 2020 | 43940 | 6591 | 549 | Early COVID-19 vaccine reports (Dec 2020); otherwise routine. |
| 2021 | 647830 | 97175 | 8098 | Massive spike due to COVID-19 vaccines; ~700,000 total by year-end. |
| 2022 | 274730 | 41210 | 3434 | High but lower than 2021; continued COVID-19 vaccine reporting. |
| 2023 | 102320 | 15348 | 1279 | Decline as COVID-19 vaccination slowed; booster focus. |
| 2024 | 50780 | 7617 | 635 | Further decline; return to lower reporting levels. |